The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-10 in Men after Coronary Artery Bypass Grafting

Introduction: Lipid metabolism disorders, especially raised levels of cholesterol and triglycerides increases the risk of atherosclerosis. The adenosine triphosphate ABC transporter family plays an important role in reverse cholesterol transport process; Therefore, the aim of this study was to investigate The effect of combined training Courses on the Expression of ABCG4 Gene and interleukin 10 in men after coronary artery bypass grafting. Methods: In this semi-experimental study, the statistical sample consisted of 20 middle-aged men who previously had undergone coronary artery bypass grafting. After selection, these individuals were divided into two groups of control (n=10) and combined training (n=10). The subjects of the training group performed combined aerobic-resistance exercises 3 sessions per week for 24 weeks. At the beginning and end of training sessions, blood samples were obtained to isolate mononuclear cells and extract mRNA. Real-Time PCR was used for gene expression analysis, and IL-10 was determined by ELISA. SPSS software version 16 was used for data analysis. Results: Eight weeks of combined training resulted in a significant increase in ABCG4 gene expression (P = 0.001) and interleukin 10 (P = 0.001) in the combined training group compared to the control group. Conclusions: It seems that exercise as by effecting on ABCG4 gene expression and interleukin 10, involved in fat metabolism, improves reverse cholesterol transfer process.